sodium selenite toxicity

* Sodium Selenite may cause mutations. [7] In 2000, the U.S. Institute of Medicine set the adult Tolerable upper intake levels (UL) for selenium from all sources - food, drinking water and dietary supplements - at 400 g/day. In contrast, sodium selenite did not break DNA (lane 2) unless it was mixed with glutathione (lane 4), . When an overload of selenium (in its natural or artificial form) accumulates in the body, it can also cause damage to the heart, liver, eyes, kidneys, may contribute to the onset of diabetes and even be carcinogenic. WGK 2. The secondary endpoint was primary response evaluation. The need for supplemental selenium in U.S. pig diets is largely dependent on the soil type in which the corn and soybeans are grown for inclusion in pig diets. [Abstract] Study Data Protocol Toxicity and Carcinogenicity Studies 3-Month Evaluation of the Toxicity (C04308) of Sodium Selenite (10102-18-8) in F344/N Rats Exposed via Dosed Water Don't take my word for it, you can click on this link and read an actual MSDS SARA Section 313 (specific toxic chemical listings) 10102-18-8 Sodium selenite California Proposition 65 Prop 65 - Chemicals known to cause cancer Substance is not listed. The pentahydrate Na2SeO3(H2O)5 is the most common water-soluble selenium compound. EINECS: This product is on the Lastly, it is essential to know that you should not use selenite damaged by water or saltwater, as the stone no longer has its beneficial properties. Excesses of any form of selenium can be toxic but there is a very safe dosage range where sodium selenite can treat cancer without any adverse side effects or toxicity. Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The chronic toxic dose of selenium as Sodium Selenite for humans was estimated to be between 2.4 and 3 mg per day. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) Toxic by ingestion, inhalation and skin absorption. Sodium selenite is a salt; a selenium compound that is water-soluble. However, Sodium (Sodium Selenite Pentahydrate) nitrite treatment of pregnant guinea pigs with 60 . * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. MSDS Name: Sodium Selenite, Anhydrous, 44-46% se Catalog Numbers: AC200730000, AC200730250, AC200731000 Synonyms: Disodium Selenite; Selenious Acid Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 (1,3) . | Explore the latest full-text research PDFs, articles, conference papers, preprints and more on TOXIC ACTIONS. Sodium selenite is a colorless toxic solid. Based on the preceding review, the optimal form of Se for nutritional supplementation and cancer prevention would be expected to have distinctly low toxicity and to possess good . In one study, male and female Wistar rats were given dietary sodium selenite at concentrations of 0, 0.5, and 2.0 ppm in a semipurified high-protein diet for an entire lifetime (Tinsley et al., 1967; Harr et al., 1967). As a result . In a Cochrane review of selenium and cancer prevention studies, compared with the lowest category of selenium intake, the highest intake category had a 31% lower cancer risk and 45% lower cancer mortality risk as well as a 33% lower risk of bladder cancer and, in men, 22% lower risk of prostate cancer [ 37 ]. Several lines of evidence show epigallocatechin-3-gallate (EGCG), a predominant component of green tea catechins with numerous health benefits, can ameliorate the toxicity of many agents. Sodium selenite 99%; CAS Number: 10102-18-8; EC Number: 233-267-9; Linear Formula: Na2SeO3; find Sigma-Aldrich-214485 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich . More soluble compounds, for example, sodium selenite, are more toxic than the less soluble elemental selenium, selenium sulfide, or selenium disulfide. (EPA, 1998) . Furthermore, it can damage the heart, liver, eyes, kidneys, and other organs, raising the risk of diabetes and even cancer. According to the classification standard of acute toxicity, sodium selenite belongs to the category 5 (highly toxicity). * Contact can severely irritate and burn the skin and eyes with possible eye damage. Animal studies have reported that selenium supplementation, as sodium selenate, sodium selenite, and organic forms of selenium, results in a reduced incidence of several tumor types. Maruti Chemicals. Why is selenite toxic? Based on our research, I would prefer that Se be 50 percent sodium selenite and 50 percent organically-derived (e.g., Sel-Plex). Year . . This salt is a colourless solid. Repeated or prolonged exposure to the substance can produce target organs damage. . Sodium selenate and sodium selenite are used as supplements to poultry and livestock feed to promote growth and prevent selenium deficiency diseases. Selenium dioxide is highly to moderately toxic, with oral LD50 values in rodents from 20 to 70 mg kg 1. excessive doses of selenium result in intoxication, which is characterised by continuous vomiting, garlicky breath, mucosal irritation, abdominal pain, hypersalivation, haemolysis, necrosis of the liver, cerebral and pulmonary oedema, coma and death. The bioactivities and toxicities of inorganic sodium selenite, organic selenomethionine (SeMet), and Se-methylselenocysteine (SeMSC) have been extensively investigated. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE. Sodium selenate is the inorganic compound with the formula Na 2 SeO 4, not to be confused with sodium selenite.It exists as the anhydrous salt, the heptahydrate, and the decahydrate. Soluble in water and more dense than water. Safety Data Sheet (SDS) for Sodium Selenite Revision Date: Jan 07, 2016 Version: A/1 4 / 15 P333+P313 If skin irritation or rash occurs: Get medical advice/attention. Repeated or prolonged exposure to the substance can produce target organs damage. The disodium salt of selenious acid. Selenite is non-toxic. 8 Fl Oz (Pack of 1) 4.4 out of 5 stars 298 . Disodium selenite pentahydrate is a hydrate that is the pentahydrate form of disodium selenite. The crystal structure of the anhydrous salt has been variously reported as tetragonal or monoclinic. Typical therapeutic dosage is in the range of 10-30 mg per day. A broad category of chemical actions with harmful or deadly effect on living organisms. Flash Point(F) Not applicable . During pregnancy, a low Se status can increase the risk of oxidative stress. Chat now for more business. Sodium selenite is an ingredient found in roughly 90% of all commercial pet foods. NA-SEIT-02-C.5HYD , NA-SEIT-03-C.5HYD , NA-SEIT-04-C.5HYD , NA-SEIT-05-C.5HYD CAS #: 26970-82-1 Relevant identified uses of the substance: Scientific research and development Supplier details: American Elements 10884 Weyburn Ave. The best protection is to However, some studies in rats suggested that Sodium Selenite was 2.94 times more toxic than an alternative form of Selenium called Selenium Yeast. Sodium selenite appears as a white colored crystalline solid. TOX-38 Toxicity Studies of Sodium Selenate and Sodium Selenite (CASRNs 13410-01- and 10102-18-8) Administered in Drinking Water to F344/N Rats and B6C3F1Mice. from inhalation exposure, sodium selenite to have extreme toxicity from oral exposure, and elemental selenium to have low toxicity from oral exposure. When heated to decomposition, may emit toxic fumes of selenium and sodium oxide. Mutagenesis. Prop 65 - Developmental toxicity, female Substance is not listed. Selenium sulfide has been linked with the occurrence of liver and lung tumors in mice and rats following oral exposure. Furthermore, saltwater will damage selenite even more, as salt is corrosive and highly abrasive on stones like selenite. The US Institute of Medicine set the adult Tolerable upper intake limits (UL) for selenium from all sources - food, drinking water, and dietary supplements - at 400 g/day in 2000. . : Sodium selenite: 100 lbs. Both the acid and elemental form are well absorbed through the lungs and gastro-intestinal tract. Read-across from sodium selenite and selenious acid to barium/zinc selenite Based on a comparison between toxicity reference values of zinc compounds and selenium compounds, it can safely be assumed that the selenium/selenite moiety of zinc selenite is generally of higher toxicological relevance than the zinc cations. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs." (1,2) Increasing doses of sodium selenite (4, 10, 14 and 18 mg/kg) were administered in separate groups of mice and rats. Toxicological information Acute Toxicity Product Information Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation Sodium selenite LD50 = 7 mg/kg ( Rat ) Not listed Not . Meanwhile, the acute toxicity test results of bio-Se obtained from yeast were shown in Table 2. 11. SELENITE, SODIUM : figure/table : figures and tables of selenium concentration over time (% of administered dose) . P362+364 Take off contaminated clothing and wash it before reuse. Vigasov D, et al. Brand. Ingestion of about 1000 mg of sodium selenite caused a condition similar to arsenic poisoning with death in 5 hr (Moeschlin, 1965 ). Aquatic toxicity: 10102-18-8 sodium selenite Oral LC50 / 96 h 2.75 mg/L (Oncorhynchus mykiss) It has a role as a nutraceutical. (Sodium Selenite) DATE PREPARED: 10/13/2015 Page 7 of 8 SARA Section 313: Sodium Selenite (CAS No. (45.36 kg) Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). It is considered an indispensible trace mineral. SECTION 1. In cats, selenium toxicity can cause hair and coat loss, brittle nails, digestive disturbances, skin rashes, and nervous disorders. Indeed, selenium was initially known as a toxic element in animal poisoning by selenium-rich plants . Se toxicity lead to a condition called selenosis i.e., garlic odor of the breath, gastrointestinal disorders, hair loss, sloughing of nails, and neurological damage. SARA 302/304/311/312 extremely hazardous substances: Sodium selenite SARA 313 toxic chemical notification and release reporting: Sodium selenite CERCLA: Hazardous substances. Mutagenesis 25: 155-162. In extreme selenosis cirrhosis of the liver, pulmonary edema, or even death can occur. 1-48 of 132 results for "sodium selenite" RESULTS. The best . Abstract Selenium, an essential trace element, can also be toxic at higher levels of exposure. Sodium selenite (Na 2 SeO 3) is a toxic inorganic salt that is highly soluble in water and insoluble in organic solvents. Investigations on the role of base excision repair and non-homologous end-joining pathways in sodium selenite-induced toxicity and mutagenicity in Saccharomyces cerevisiae. Safe Storage (GHS): P403+P233 Store in a wellventilated place.. Keep container tightly clos 3, 8 selenium presents a nutritional conundrum because of its dual status as an essential but Sodium selenite significantly increases TBARS production (about 11.421.31pmol TBARS/mg protein compared to about 40.21 pmol TBARS/mg protein).The magnitude of increase was more than 3-fold at 5 mmol relative to the control. These are white, water-soluble solids. This study aimed to compare the effects of BSA-stabilized Se nanoparticles (SeNPs, Se0) (BSA-bovine serum albumin . "Sodium selenite may be toxic to blood, kidneys, liver, skin, central nervous system. Unfortunately, there have not been identical studies done on dogs to see if that is also the case for them, so it's difficult to know if we can make assumptions based on this. . Sodium selenite Revision Date 24-Dec-2021 Hazardous Polymerization Hazardous polymerization does not occur. Prop 65 - Developmental toxicity Substance is not listed. Arterial blood was taken before dosing and at 60 and 120 minutes when the pigs were killed. Summary of experiments to determine the toxicity of single doses of selenium in the form of sodium selenite administered orally to horseSy muleSj cattle, and swine Species and No. Boosts Immune System | Helps Break Down and Reduce Toxic Metals | 96 Servings | 8 fl oz. The high conversion of selenium ions to selenium nanoparticles (SeNPs) was achieved by a reaction mixture of 0.1 g bovine serum albumin and 0.1 g sodium selenite at a reaction temperature of 121C for 20 min duration. The ingredient is even utilized as a selling point, which is very strange to say the least given its toxic properties. In contrast, selenized yeast appears to have a higher selenium bioavailability than sodium selenite. Sodium selenite is the most toxic compound when ingested orally. I think you might be confusing sodium selenite (the ion) with selenite (the mineral). Formulating pig diets: Selenium toxicity, deficiency . 61.15.1.3 Toxicity to Humans Accidental and Intentional Poisoning Apparently there is no record of human poisoning by sodium selenate. In contrast, sodium selenite did not break DNA (lane 2) unless it was mixed with glutathione (lane 4), . Because selenium is an essential element, it is mainly used in feed additives and food industry. At high or toxic levels as much as 30 to 60% of selenium can be excreted via expired air , predominantly as dimethylselenide. * Contact can severely irritate and burn the skin and eyes with possible eye damage. To formulate the chemicals, we use finest quality of compounds, procured from the most reputed and trusted vendors. 172.94 g/mol. Statistical results of acute toxicity test for sodium selenite. The heaviest concentration . Common Name: SODIUM SELENITE CAS Number: 10102-18-8 DOT Number: UN 2630 ----- HAZARD SUMMARY * Sodium Selenite can affect you when breathed in and by . Common Name: SODIUM SELENATE CAS Number: 13410-01- DOT Number: UN 2630 ----- HAZARD SUMMARY * Sodium Selenate can affect you when breathed in and may be absorbed through the skin. This method is a simple, low cost green synthesis alternative to chemical synthesis. The National Institute of Health states that toxicity is very rare for sodium selenite. Sodium selenite and sodium selenate have also been approved as feed additives at a maximum concentration of 0.5 mg selenium/kg feed (complete feed). The anhydrous salt is used in the production of some glass. Too much selenium -- more than 400 micrograms per day -- causes selenosis, a toxicity linked to bad breath, skin rashes and abnormal function of the nervous system. Handle with extreme caution. Handle with extreme caution. Ionic Selenium Supplement 100ml | Contains Selenium in The Form of Sodium Selenate | Easy to Consume Selenium Liquid | Only Active Ingredients & Purified Water . View Article WGK. Thirteen-week toxicity studies were conducted by administering the chemicals to groups of male and female F344/N rats and B6C3F1 . Sodium selenite "may be toxic to blood, kidneys, liver, skin, central nervous system. Stable in air. Sodium selenite is the inorganic compound with the formula Na2SeO3. Results and conclusion: MTD was defined as 10.2 mg/m(2), with a calculated median plasma half-life of 18.25 h. The maximum plasma concentration of selenium from a single dose of selenite increased . However, elevated concentrations of Se in the body can also cause oxidative stress. Abstract. Similarly, a human has a 50% chance of dying after consuming only 108 milligrams. * Breathing Sodium Selenite can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath. Laboratory Findings According to the 1986 edition of the Handbook of the Toxicology of Metals, daily intake of about one milligram of selenium as selenite can be toxic. Prop 65 - Developmental toxicity, male Substance . Live weight Dosage of Method of administration Selenium as sodium selenite per pound of body weight Result Sodium selenite Water Horse: 775 14.22 764 875 Pounds 1,185 970 Contact may irritate skin, eyes and mucous membranes. 2010; 25:155-162. European Inventory of Existing Chemicals (EINECS) EC Classification In animals, the minimum lethal dose for intravenous administration of sodium selenite is between 1.5 and 3 mg/kg [22, 23]. Dose limiting toxicities (DLTs) of the combination of sodium selenite plus abiraterone are defined as: Any Grade 3 non-hematologic toxicity (possibly, probably, or definitely-related adverse event) Any Grade 3 thrombocytopenia with bleeding Any Grade 4 thrombocytopenia persisting > 7 days Any Grade 4 neutropenia persisting > 7 days Full-Text research PDFs, articles, conference papers, preprints and more on ACTIONS... And sodium selenite ( CASRNs 13410-01- and 10102-18-8 ) Administered in Drinking Water to F344/N rats B6C3F1Mice. Notification and release reporting: sodium selenite CERCLA: Hazardous substances h 2.75 mg/L Oncorhynchus! Se0 ) ( BSA-bovine serum albumin meanwhile, the acute toxicity test results sodium selenite toxicity toxicity. 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